LB1568 Role of IL-36 in acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis

Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis

BACKGROUND Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). OBJECTIVE To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis. METHODS This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of ...

Acute generalized exanthematous pustulosis (AGEP) in Singapore

Results There were 20 cases of AGEP that were seen during the study period. Of which there are 8 males (40%) and 12 (females (60%) with a mean age of 60 years (Range : 24-85 years). In addition to extensive pinpoint pustules, other cutaneous features included facial edema, target-like lesions with rim of pustules and edema bulla. Common laboratory derangement included leukocytosis, eosinophilia...

Terbinafine-induced acute generalized exanthematous pustulosis.

Terbinafine is an allylamine antifungal agent, effective in the treatment of dermatomycoses. Many cutaneous adverse reactions have been reported (in about 3% of treated patients). Furthermore terbinafine has been associated with pustular eruptions, as well as the induction and exacerbation of pre-existing psoriasis and acute generalized exanthematous pustulosis (AGEP). AGEP is an uncommon asept...

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

Acute generalized exanthematous pustulosis (AGEP) is a severe and rare eruption that develops mostly from factors related to drugs. It is characterized by a fever and a pustular eruption on the erythematous skin with an acute onset and without follicular localization. Etiopathogenesis has not yet been fully explained. Although it is similar to pustular psoriasis, its clinical, historical and hi...